Stroke is considered as the second leading cause of death around the world. It is characterized by a blockage of blood flow in the brain that leads to the irreversible damage of brain cells. Researchers from the University of Manchester in the UK have discovered that a drug that is already approved to treat other conditions can also limit stroke damage as well as also promote cell repair. The study findings is published in the journal Brain, Behavior and Immunity.
The researchers investigated the effect of the anti-inflammatory drug called interleukin-1 receptor antagonist or IL-1Ra on rats after they suffered a stroke. The said drug is already approved for the treatment of diseases such as rheumatoid arthritis. Early stage clinical trials for treatment of stroke has already been conducted in Manchester.
The researchers found out that rats suffering from stroke and then treated with IL-1Ra not only reduced brain damage resulting from the early stages of stroke, but may also aid in repairing the damage. The researchers also noticed an increase in the new brain cell numbers several days later. The results were promising regardless if the rats were old, young, lean or obese.
The researchers further looked into the effect of IL-1Ra on neurogenesis in the rats’ brains. They discovered that the drug not only increased the proliferation of stem cells, it also significantly enhance neuroblast migration and the number of newly born neurons after the restriction of blood flow that results from the stroke.
Source: Medical News Today